Integrated Aging Studies Databank and Repository (IASDR)

The Integrated Aging Studies Data Bank and Repository (IASDR) is a web-based data management system that houses data from WF OAIC studies in a common structured format, readily allowing the integration of summary statistics and data across multiple studies. The IASDR also provides information on availability of activity monitoring, imaging data and WF OAIC Biospecimens Repository.

The IASDR has 3 components:

  1. a publicly accessible registry (WF Pepper Study Registry) to query metadata that indicates the availability of components of the common assessment battery, activity monitoring, imaging data (e.g. DEXA, CT and MRI), and biospecimens (e.g. serum, plasma, muscle, adipose, urine and DNA) across studies; WF Pepper Study Registry is embedded in the OAIC CC Pepper Study Registry.
  2. a search engine of descriptive statistics providing more granular details for selected common assessment battery based on filtering criteria (e.g., study, age, gender/sex, etc.), to which WF OAIC investigators can request password to access; and
  3. a quality-controlled, analysis ready participant-level dataset comprising the common assessment battery that is updated quarterly (secured).
    Available data in the common assessment battery include:
    • Demographics, gender, age, race/ethnicity
    • Body Composition (DXA)
    • Physical Performance: Short Physical Performance Battery (SPPB), Expanded SPPB, Grip Strength, Gait Speed (4 meter and 400 meter, GAIT Rite)
    • Disability measures: PAT-D, MAT-sf
    • Cognition: MoCA, DSST, MMSE
    • Depression: CES-D
    • Biomarkers:IL-6, TNF-alpha CRP, sTNF-R1 Adiponectin, Leptin

Biospecimen Repository

An WF OAIC Biological Specimen Repository and Distribution Center developed a centralized system for the proper collection, transfer, and storage of biological tissue to be used for conducting future ancillary studies by investigators in aging related research.

As of January 2023, the Repository holds >200,000 cryovials of serum or plasma from over 4,500 participants, 5,290 DNA samples, and 1,973 participants with either stored adipose tissue or muscle hundreds of pre/post sets of stored muscle from participants in different intervention studies. All samples are collected from study participants enrolled in research protocols at Wake Forest University or Wake Forest University School of Medicine. Written informed consent is obtained from each participant providing permission to have their samples stored for future, undesignated research.

IRB approval is required to receive samples and priority is given to new investigators and those within the OAIC network.

Availability of biospecimens can be accessed through WF Pepper Study Registry.

Potential Uses

Novel Hypotheses Testing The IASDR is a valuable resource for efficient testing of novel hypotheses with adequate sample sizes across a broad range of diseases and conditions related to the OAIC's theme.

Examples of publications using the IASDR:

Sample size determination The IASDR provides a wealth of preliminary data for use in sample size calculations. Intervention effects and estimates of variability/association often can be derived from prior OAIC studies.